Suicidal ideation in an adolescent clinical sample: Attachment patterns and clinical implications

Investigated the relationship between attachment patterns and suicidal ideation in a clinical sample of 116 adolescents (aged 10–17 yrs). Ss were assessed on level of current ideation through self-report questionnaires. Lethality of methods contemplated was also rated on a subset of the sample (16 Ss) who, in addition to endorsing current suicidal ideation, presented a plan on a diagnostic interview. Quality of attachment to caregivers based on a semistructured clinical interview was assessed using K. Bartholomew\u27s (see record 1990-30882-001) 2-dimensional, 4-category model of attachment. Categorical analyses indicated that youth with predominantly fearful or preoccupied attachment were more likely to endorse suicidal ideation than were predominantly secure or dismissing youth. Severity of suicidal ideation was positively correlated with ratings of fearfulness and negatively correlated with ratings on the secure and dismissing patterns. Greater lethality in methods of contemplated suicide was positively correlated with preoccupied tendencies. The importance of attachment theory for understanding the factors underlying suicidal ideation in troubled youth is discussed and implications for therapeutic intervention are presented

Tip-Enhanced Fluorescence Microscopy at 10 Nanometer Resolution

We demonstrate unambiguously that the field enhancement near the apex of a laser-illuminated silicon tip decays according to a power law that is moderated by a single parameter characterizing the tip sharpness. Oscillating the probe in intermittent contact with a semiconductor nanocrystal strongly modulates the fluorescence excitation rate, providing robust optical contrast and enabling excellent background rejection. Laterally encoded demodulation yields images with <10 nm spatial resolution, consistent with independent measurements of tip sharpness

Efficient rigorous numerics for higher-dimensional PDEs via one-dimensional estimates

We present an efficient rigorous computational method which is an extension of the work Analytic Estimates and Rigorous Continuation for Equilibria of Higher-Dimensional PDEs (M. Gameiro and J.-P. Lessard, J. Differential Equations, 249 (2010), pp. 2237-2268). The idea is to generate sharp one-dimensional estimates using interval arithmetic which are then used to produce high-dimensional estimates. These estimates are used to construct the radii polynomials which provide an efficient way of determining a domain on which the contraction mapping theorem is applicable. Computing the equilibria using a finite-dimensional projection, the method verifies that the numerically produced equilibrium for the projection can be used to explicitly define a set which contains a unique equilibrium for the PDE. A new construction of the polynomials is presented where the nonlinearities are bounded by products of one-dimensional estimates as opposed to using FFT with large inputs. It is demonstrated that with this approach it is much cheaper to prove that the numerical output is correct than to recompute at a finer resolution. We apply this method to PDEs defined on three- and four-dimensional spatial domains

Rigorous computation of smooth branches of equilibria for the three dimensional Cahn-Hilliard equation

In this paper, we propose a new general method to compute rigorously global smooth branches of equilibria of higher-dimensional partial differential equations. The theoretical framework is based on a combination of the theory introduced in Global smooth solution curves using rigorous branch following (van den Berg et al., Math. Comput. 79(271):1565-1584, 2010) and in Analytic estimates and rigorous continuation for equilibria of higher-dimensional PDEs (Gameiro and Lessard, J. Diff. Equ. 249(9):2237-2268, 2010). Using this method, one can obtain proofs of existence of global smooth solution curves of equilibria for large (continuous) parameter ranges and about local uniqueness of the solutions on the curve. As an application, we compute several smooth branches of equilibria for the three-dimensional Cahn-Hilliard equation

African-American patients with cancer Talking About Clinical Trials (TACT) with oncologists during consultations: evaluating the efficacy of tailored health messages in a randomised controlled trial—the TACT study protocol

Introduction Low rates of accrual of African-American (AA) patients with cancer to therapeutic clinical trials (CTs) represent a serious and modifiable racial disparity in healthcare that impedes the development of promising cancer therapies. Suboptimal physician–patient consultation communication is a barrier to the accrual of patients with cancer of any race, but communication difficulties are compounded with AA patients. Providing tailored health messages (THM) to AA patients and their physician about CTs has the potential to improve communication, lower barriers to accrual and ameliorate health disparities. Objective (1) Demonstrate the efficacy of THM to increase patient activation as measured by direct observation. (2) Demonstrate the efficacy of THM to improve patient outcomes associated with barriers to AA participation. (3) Explore associations among preconsultation levels of: (A) trust in medical researchers, (B) knowledge and attitudes towards CTs, (C) patient-family member congruence in decision-making, and (D) involvement/information preferences, and group assignment. Methods and analysis First, using established methods, we will develop THM materials. Second, the efficacy of the intervention is determined in a 2 by 2 factorial randomised controlled trial to test the effectiveness of (1) providing 357 AA patients with cancer with THM with 2 different ‘depths’ of tailoring and (2) either providing feedback to oncologists about the patients\u27 trial THM or not. The primary analysis compares patient engaged communication in 4 groups preconsultation and postconsultation. Ethics and dissemination This study was approved by the Virginia Commonwealth University Institutional Review Board. To facilitate use of the THM intervention in diverse settings, we will convene ‘user groups’ at 3 major US cancer centres. To facilitate dissemination, we will post all materials and the implementation guide in publicly available locations

Thermo-responsive, UV-active poly(phenyl acrylate)-b-poly(diethyl acrylamide) block copolymers

The homopolymerization of phenyl acrylate (PA) was investigated for the first time by nitroxide mediated polymerization (NMP) with the succinimidyl form of the SG1-based unimolecular initiator 2-[N-tert-butyl-2,2-(dimethylpropyl)-aminooxy]propionic acid (BlocBuilder MA). The control of PPA homopolymerization was improved by the use of 15 mol% additional free nitroxide SG1 ([tert-butyl[1-(diethoxyphosphoryl)-2,2-dimethylpropyl]amino]oxidanyl) and dispersities, Mw/Mn, of around 1.2 were achieved. A PPA homopolymer was then successfully chain-extended with diethyl acrylamide (DEAAm) to form a block copolymer of PPA-b-PDEAAm where the PDEAAm segment is thermo-responsive, while the PPA block is potentially UV-active. The thermo-responsive behavior of the block copolymer in 0.5 wt% aqueous solution was studied by UV-Vis spectrometry and dynamic light scattering (DLS), indicating cloud point temperatures of 26–30°C, close to that reported for PDEAAm homopolymers

Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients.

The purpose of this study was to evaluate the performance of a commercially available CyberKnife system with a multileaf collimator (CK-MLC) for stereotactic body radiotherapy (SBRT) and standard fractionated intensity-modulated radiotherapy (IMRT) applications. Ten prostate and ten intracranial cases were planned for the CK-MLC. Half of these cases were compared with clinically approved SBRT plans generated for the CyberKnife with circular collimators, and the other half were compared with clinically approved standard fractionated IMRT plans generated for conventional linacs. The plans were compared on target coverage, conformity, homogeneity, dose to organs at risk (OAR), low dose to the surrounding tissue, total monitor units (MU), and treatment time. CK-MLC plans generated for the SBRT cases achieved more homogeneous dose to the target than the CK plans with the circular collimators, for equivalent coverage, conformity, and dose to OARs. Total monitor units were reduced by 40% to 70% and treatment time was reduced by half. The CK-MLC plans generated for the standard fractionated cases achieved prescription isodose lines between 86% and 93%, which was 2%-3% below the plans generated for conventional linacs. Compared to standard IMRT plans, the total MU were up to three times greater for the prostate (whole pelvis) plans and up to 1.4 times greater for the intracranial plans. Average treatment time was 25 min for the whole pelvis plans and 19 min for the intracranial cases. The CK-MLC system provides significant improvements in treatment time and target homogeneity compared to the CK system with circular collimators, while maintaining high conformity and dose sparing to critical organs. Standard fractionated plans for large target volumes (&gt;100 cm3) were generated that achieved high prescription isodose levels. The CK-MLC system provides more efficient SRS and SBRT treatments and, in select clinical cases, might be a potential alternative for standard fractionated treatments. PACS numbers: 87.56.nk, 87.56.bd